![]() ![]() ![]() And finally, his rocks, much to the chagrin of his wife. Elementary during retirement for his granddaughter and all the other kids who learned from him. ![]() He didn’t stop there, becoming a substitute teacher at Washington Ave. He was also a proud Rainbow Dad of Zia Assembly #49 for over 15 years always involved with the choral departments at both Roswell and Goddard High Schools. And then there was Tastee-Freeze! He loved nurturing the young and took great pride as a Scout Master as many of the young men made it to Eagle Scout. He loved to tell his old stories about growing up in Hagerman and living on the Caprock Ranch his years at the New Mexico Military Institute, graduating the last year it was a four-year college serving the United States in the Army bookkeeping and managing several businesses. While Alzheimer’s took his mind it never took his spirit, sense of humor, smile or his orneriness! An old cowboy to the end with his grace and bravery. 1953 JC-1955 SC ~ 1 82 of Roswell was reunited in heaven with his bride of 61 years, Betty Andrus. Anderson, III brother-in-law of Cheryl (Craig) Daniels and the late Linda DeLuca also survived by many nieces and nephews.Īndrus, Lawrence R. Anderson, Pamela (Joerg) Anderson-Goeing and Krisann (Ronald) Sutherland loving grandfather of Cara, Ashley, Kelsie, Amy, Kristopher, Kathryn, Lauren, Ian, Erin, Gillian and Harrison great-grandfather of Jewelya, Cameron and Zachary dear brother of the late Augustus “Gus” E. Beloved husband of Patricia (nee Loudy) Anderson devoted father of Leonard “Randy” R. Speer 1933 JC, who was killed in a Polo Game, is appropriate at this ceremony.Īnderson, Leonard R. Published by Elsevier B.V.A quote from the 1933 Bronco about a cadet, George O. Together, triptonide exerts potent anti-lymphoma effect with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn downstream ERK and ATK signal pathways, providing an attractive drug candidate for development of novel anti-lymphoma therapeutics.Īnti-cancer ERK Lymphoma Lyn Triptonide.Ĭopyright © 2017. Additionally, triptonide significantly enhanced p38 phosphorylation. Molecular studies revealed that triptonide markedly inhibited oncogenic Lyn transcription through suppressing the promoter activity of the gene, and that it remarkably reduced both total and phosphorylated Lyn proteins, and diminished Lyn downstream ERK and ATK signal pathways. Cell biological studies showed that triptonide at the doses of 2.5-10nM notably suppressed B-lymphoma cell colony-forming capability, and that triptonide at the dose of 20nM promoted apoptosis through activation of PARP and caspase 3, but reduction of BCL2 protein levels in the lymphoma cells. Strikingly, triptonide at a dose of 5mg/kg/day almost completely inhibited the lymphoma growth in human lymphoma cells-xenografted mice without obvious side effects, particularly the tumors in 6 mice among the 8 xenografted mice were completely eradicated in vivo. Here we show that triptonide, a small molecule purified from the herb Tripterygium wilfordii Hook F, potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7nM and 4.8nM, respectively. ![]() The goal of this study is to explore powerful and low toxic Lyn-targeted anti-lymphoma agent. Hence, the oncogenic Lyn has recently been targeted for novel anti-lymphoma drug discovery however, the effective Lyn-targeted drug for lymphoma treatment with low toxicity is absent in the clinical setting. Lyn is a proto-oncogene overexpressed and constitutively activated in lymphoma, and plays an important role in lymphoma initiation and malignant progression. ![]()
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